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L-Glutamine
03-26-2013, 07:27 PM
Post: #1
L-Glutamine
Subject: L-Glutamine
Author: Marie-Blanche

I am researching leaky gut treatments. I come to believe that all the burning, itching etc in my skin is candida toxins leaked from... leaky gut.

Is L-Glutamine advisable for candida people? I have a serious yeast allergy - am allergic to candida and when leaky gut kicks in, am then allergic to all grains since they have mould on it - including psyllium. So repairing my leaky gut is urgent

I read that L-Glutamine is great for that. Is it fermented or mouldy? Its an amino acid, so does it cause adverse reactions in candida people?

* Response...

Subject: Re: L-Glutamine
Author: Polly

It is advisable to get the dysbiosis under control as much as possible before trying L-glutamine. Otherwise, the bad bacteria may create unfavorable products from the L-glutamine.

What follows are some excerpts from the forum book about glutamine.

Glutamine is needed to heal the intestines and it is important to the immune system. It is a good guess that anyone who has had yeast overgrowth will be low on glutamine. However, glutamine will increase the ammonia burden on the body. Not everyone will be able to tolerate it. Before you take glutamine, you should make sure your taurine levels are adequate, because the glutamine may lower taurine. Especially if you are mercury poisoned or if you have fibromyalgia, you should make sure your citrulline and arginine levels are adequate before trying glutamine.

Often, glutamine is prescribed to help repair your intestinal lining. Please be aware that it interacts with other amino acids. In fact, no amino acid acts completely by itself. In the case of glutamine, it can lower branch chain aminos, lower taurine and it might raise citrulline, arginine, and alanine aminos. [13]

the intestines, the glutamine will convert into glutamate and release ammonia. [14] The ammonia can interfere with many bodily processes including interference with alpha-ketoglutaric acid, which is needed for energy production. Long time exposure to excess ammonia can lead to permanent nerve damage.

Since many of us might be low on the amino acids used to remove ammonia, it might be a very good idea to bring up the level of these amino acids before starting glutamine. Alpha-ketoglutaric acid helps keep ammonia under control, and it is fairly likely that it is low. I also believe that low taurine levels should be corrected before starting the glutamine. I think that amino acid supplementation must be used in a particular treatment sequence for best results. The trick is to find out that sequence.

Shelley: Has anyone experienced major brain fog effects from taking glutamine?

Mary in Pennsylvania: Shelley, YES!!! I had major brain fog from all the ammonia created from pathogenic bacteria and candida in my gut. Then when I started to use the glutamine it got even worse, but I didn’t realize it was the glutamine making me worse (even the doctor didn’t know). It was this forum that helped me get the situation under control. I used some supplements that targeted getting rid of the excess ammonia. The supplement that helped me the most was alpha-ketoglutarate, plus I stopped taking the glutamine for a while. Now I take it but sparingly. I might take a teaspoon of the powder that is the equivalent of about 5 grams once or twice a week.

One more thing about glutamine. I do a lot of research on supplements before I just start using them and I never saw anything about the excess ammonia that is created. The only caution that I saw in print was supplementing with glutamine pulls water out of the colon and therefore it was necessary for people to take high fiber and drink lots of liquid to overcome possible constipation. Oh, I do remember one article but can’t find it now that indicated the doctors’ concern on excess (I think) hydrogen or nitrogen impacting the brain. This whole thing has taught me a very valuable lesson…Keep a journal and track ALL symptoms. Then you have a better idea of what supplement is causing what symptoms.

Mrs. Generic: How much glutamine are people using for their leaky gut?

Polly: Typical doses are from 3 g to 8 g per day, although doctors have used up to 40 g per day to stop diarrhea. The best price I’ve seen on glutamine is from Cambridge Nutraceuticals. (800) 265-2202 This company can also provide you with some papers on glutamine and the book The Ultimate Nutrient Glutamine.

If you try glutamine, divide your doses throughout the day. It can cause constipation. Be careful if you have weak kidneys. Large amounts of added protein like glutamine may be hard on weak kidneys. Make sure you have adequate supplies of coenzyme B6 before using glutamine. Coenzyme B6 is needed to convert glutamic acid into GABA. Without adequate coenzyme B6, extra glutamine will certainly cause an imbalance that would contribute to seizures. Anyone prone to seizures should be very wary of using glutamine, because glutamine will convert to the excitotoxin glutamate and will release ammonia, both of which could contribute to seizures.

Since all the aminos are interconnected, a blend or a particular sequence of support may be necessary. You might want to make sure your branch chain aminos, your taurine, and the aminos that help remove ammonia are adequate before trying the glutamine. This is where an amino acid assay and some professional help come in very handy. But there is so much to learn about aminos, that even the experts don’t know everything. So don’t over-do any single amino, and pay close attention to how you react/feel.
Andy: Don’t worship a blood test like the amino acid assay. Use it as guidance to the extent it is helpful. The idea is to make you healthy, not to make a piece of paper that comes from the laboratory have wonderful numbers on it.

3 years later — Polly: Our concerns about glutamine increasing ammonia exposure have finally been addressed. There is a new product called PERQUE Endura-Guard or Ultra Glutamine. It is glutamine combined with PAK. PAK helps mop up the ammonia by recycling glutamate back to glutamine. PAK is Pyridoxal alpha-ketoglutarate. Not only does PAK contain alpha-ketoglutarate, but PAK helps the body create coenzyme B6. I tolerate the Endura-Guard, and it seems to be helping me. (In contrast, I do not tolerate plain glutamine or plain B6.) Unfortunately, this product doesn’t address the suppression of taurine. You may still need a separate supplement of taurine.

Here is a quote from the April 2004 Townsend Letter, in an article about fibromyalgia by Russell Jaffe, PhD.

“Glutamine deficit is common. Glutamine is an important energy source in metabolically active and rapidly dividing cells. Enough L-glutamine to be clinically effective (15-60 grams/day) can lead to l-glutamate buildup as an excitoneurotoxin. Glutamate is one of glutamine’s metabolic products. A unique formulation of L-glutamine and PAK (pyridoxyl-alpha-letoglutrate) recycles the l-glutamine so that 1.5 grams of l-glutamine with 0.5 grams of PAK gives the functional effect of 15 grams of free glutamine, due to an average recycling of 10 times for each glutamine molecule."

To learn more about the Endura-guard product go to Dr. Jaffe’s PERQUE products website at http://www.PERQUE.com phone (800) 525.7372. Although the PERQUE company won't sell you their Endura-guard directly, they do have distributors who sell it. They are listed at their website. Also, you may find the Endura-guard showing up under private labels, like Ultra Glutamine. Here are a couple of places to order it. Beyond Health 1-800-250-3063 and Alternative-Medicine-and-Health.com (973) 257-1470

* Response...

Subject: Re: L-Glutamine
Author: Marie-Blanche

Thanks Polly...

You're right about bacterial dysbiosis. I hesitated before buying yet another expensive supplement and unable to take it. Glad I didn't now.

Woke up today with huge cramps and burning in the gut. Seem to have bacterial infection somehow. Some kind of bacterial diarrhea.

I've become too weak and depleted with this bloody liver cleansing + candida diet. Am down to turkey, white fish and veg. Hungry all the time.

And I still don't know what could have lodge inside the whole surface of my skin (candida itself or toxins) - it goes thick and tickling and then needles and prickley dust every time I dare eat something.

Went to a chigong healer shaking and trembling with weakness. Typing this message also shaking and trembling.

* Response...

Subject: Re: dietary fats
Author: Polly

Marie,

You said that your diet consisted of fish, turkey and vegetables. So, are you getting any fat in your diet besides fish oil? You need a proper balance of clean fats, not just fish oil. Organic butter from grass fed cows will give you some clean saturated fat as well as some vitamin K2.

* Response...

Subject: Re: dietary fats
Author: Victoria in NY

Would ghee/clarified butter provide the same benefits?

* Response...

Subject: Re: dietary fats
Author: Polly

I think so. The reason you want to get the butter / ghee from cows fed grass is that there is more vitamin K2 in it. The reason that you want organic is that animals store the pesticides they are exposed to in their fat.

* Response...

Subject: die-off....
Author: Marie-Blanche

Yes its very unlikely that I stay on this diet very long... It is just too too restrictive. I'm starving to death.

I use a bit of olive oil, but indeed the body requires oils to process oil soluble vitamins.

Actually tonight, because my stomach felt so bad, I had some Chinese medicine from my previous doctor which I got yesterday for the gut inflammation/infection; he actually thinks that candida has seeped into my skin.

His medicine is seriously antifungal (and he is one Chinese doctor who treats and accepts candida) - I had die-off from every pore in every part of my skin for hours. This feeling of prickly dust, it is so typical of candida die-off. I was shedding and shedding for more than two hours, and its still on - even from the soles of my feet, my lips, etc. Never had anything like that, even last time.

And now am really really wondering if it is candida in below my skin. Could it spread to every part of my inner skin? Still my skin is full of this weird dust feeling and tickling and giving off all kinds of candida sensations that I used to have in my gut previously.

I know in some Chinese medicine school, the dissemination of fungus inside the skin like that is admitted. Last spring with the cortisone injections, the 2 months bronchitis, etc, my immune system was so completely gone...

Gives me cold sweats to think of it.

* Response...

Subject: Re: die-off....
Author: Victoria in NY

Those are crazy die off rxns! Mine are totally different. All in my head, so to speak. I feel like my brain is swelling up and i'm about to go crazy. It is most unpleasant. I have a bag of chinese herbs in my cabinet that I am scared to take because of the die off, although I think my candida is pretty much under control. As long as i eat only my 5 foods that I'm allowed. Ok, so it's more than 5, but not by much, because I am also allergic to a bunch of stuff. And now i'm on this oxalate trip which is almost too much to think about. But something has to explain why i am so bloated and retaining tons of water all the time. Just don't know what....

Anyway, don't think about my stupid water retention. You've got enough going on over there. Feel better! Bon nuit et bon chance!

* Response...

Subject: Re: die-off....
Author: Marie-Blanche

Well this is die off but also there is leaky gut and candida toxins being released which am allergic to.

Your symptoms are interesting; brain swelling due to die-off?

I can't believe you are allowed 5 foods... What are they? What are your allergic reactions?

* Response...

Subject: Re: die-off....
Author: jee

Marie,

You couldn't possibly be reading more than I do on the Internet, I have gone insane reading stuff, this treatment, this supplement, this anti-fungal, that modality and I end up with dozens of conflicting opinions.

CoQ10 is good for some, not so for others, too much Vitamin C can hurt the kidneys, the point being that it's a never ending quest. I see people taking three dozen supplements all day, but real health is not supposed to be like that. If one can get the underlying issue addressed, then normal, healthy living is all we need.

One thing that my new TCM doctor advised me very calmly is to step back and not get carried away by every bit of information out there. I have actually heeded his advise and have stopped scouring the Internet for candida this, candida that, basically I have put my faith and trust in his expertise, as he's trying to do the best he can. I see that you are also filled with self-doubt, you think one moment, it's candida on the skin, then in the gut, then the whole body, but really, it's all idle speculation. There's no way for you to know.

The TCM doc is trained to figure that out, and they may have to experiment a little before they can settle on a medicine, so please be persistent and continue treatment, even with all the die-offs etc. If you abandon the treatment half-way, it could be detrimental in many ways. So, granted, that candida alters the brain chemistry a bit and makes us become little flaky, we must stick to one treatment method for at least 3-4 months before calling it quits.
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